What kind of
life will you live?

When there is finally a cure.

OMF’s bold approach moves research further, faster.

Complex problems require collaboration

ME/CFS and Long COVID disrupt multiple body systems. Traditional research looks at one system at a time. That just doesn’t work with multisystem disease.

As researchers struggle to understand, your old life slips away. Even your doctor doesn’t understand what is happening to you.

And you are not alone. A staggering 85 million individuals face multisystem diseases like ME/CFS and Long COVID.

It’s time for action! 

OMF recruits experts from different medical specialties to get you back to a fulfilling life.

How do you get to an answer faster?

Collaborative research is key. Every donation brings us closer to the answers we all seek.

Clear disease models

By using disease models, researchers can pinpoint targets for intervention and create more precise diagnostic tools. Ultimately, this sets the stage for successful treatments.

Accurate diagnosis

ME/CFS and Long COVID are challenging conditions to diagnose. There are no specific biomarkers or definitive tests. This delays diagnosis which prolongs suffering and uncertainty for patients.

Effective treatments

Millions of patients struggle with chronic pain, fatigue, and many other disabling symptoms. Your donation helps fund research into treatments.

Access to quality care

It's challenging to find a healthcare provider that is knowledgeable about multisystem disease. OMF funds the education of medical professionals so that you can find a doctor who understands.

You shouldn’t have to struggle alone.

We get it. We, too, are patients, parents, or partners of someone with multisystem disease. We are passionate about finding a cure.

At OMF, research is a team sport. We take a systems biology approach at our seven global Collaborative Research Centers. We have a world-renowned Scientific Advisory Board overseeing the process. Instead of waiting on publications, we share results in real-time. 

OMF believes multisystem disease should not be a life sentence but a solvable puzzle.


total Studies funded by OMF

We take a multisystem approach


Neuroendocrine System: Dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis have been observed, leading to abnormalities in stress response, sex hormone levels, and autonomic nervous system regulation. 


Immune System: The immune system is composed of white blood cells, antibodies, and other components. It defends the body against infections and diseases, helping to maintain overall health


Cardiovascular System:  The cardiovascular system, comprising the heart, blood vessels, and blood, is responsible for transporting oxygen, nutrients, hormones, and waste products throughout the body. Its efficient functioning ensures the delivery of essential substances and the removal of waste products.


Metabolism:  Metabolism involves dysregulation in energy production, particularly in ATP synthesis and mitochondrial function. Abnormalities in carbohydrate, lipid, and amino acid metabolism have also been observed. Understanding these metabolic dysfunctions can lead to symptoms such as fatigue and muscle pain.


Genetics: Genetics may contribute to an individual's susceptibility to multisystem disease, including variations in immune system genes, genes involved in energy metabolism, and genes related to neurotransmitter function. 


Pathogens:  Infections can trigger or exacerbate symptoms, leading to increased fatigue, pain, and cognitive difficulties. Pathogens can also contribute to immune system dysregulation and inflammation. 

Systems Biology

Systems biology:  Systems biology is an interdisciplinary approach that combines biology, mathematics, and computational analysis. It helps identify key pathways, biomarkers, and potential therapeutic targets, leading to personalized and more effective treatments for multisystem disease patients.


Treatments:  Treatment studies evaluate the efficacy and safety of potential interventions. By conducting rigorous clinical trials and treatment studies, researchers can refine existing therapies, develop new interventions, and provide evidence-based guidelines for healthcare providers. 



Diagnostics:  Diagnostic studies help identify specific biomarkers, imaging techniques, and diagnostic criteria that aid in distinguishing different diseases within the multisystem spectrum. 


Multiomics:  Multiomics combines various omics technologies such as genomics, transcriptomics, and proteomics. By analyzing multiple layers of biological data, multiomics provide a comprehensive understanding of the molecular mechanisms underlying multisystem diseases. 

By funding studies that examine multiple systems, researchers can see how ME/CFS and Long COVID develop. This multisystem approach can lead to more effective treatments and improved quality of life.
Hover over each system to read a description.

Our collaborators

Your life is too important to live in the shadows.

What will happen if research remains focused on one system at a time?

How will your life shrink? How many graduations, birthday parties, or everyday activities will you miss? Which close friends will quietly slip away? What will happen with your career?

Something has to change. 

Why donate to OMF?

Collaborative multisystem research will unlock the door to treatments and cures. With your help, we can get to life-changing answers faster.


Global Collaborative Research Centers

These centers are dedicated to diagnosing, treating, and ultimately curing ME/CFS and Long COVID.


World-Renowned Scientists

Our Scientific Advisory Board brings together brilliant scientists, including a Nobel laureate and five National Academy of Sciences members.

How It Works

OMF’s research process


You donate

With your support, OMF funds groundbreaking research and medical education. We bring hope to those who need it most.


Researchers get to work

We bring together top researchers in multiple specialties —  scientists dedicated to diagnosing, treating, and ultimately curing ME/CFS and Long COVID. 


Researchers collaborate

Researchers share data, collaborate and build on each other’s work. Scientific progress moves faster that way.


Light bulb moment

Even small breakthroughs can make a big difference when scientists share their ideas.


Communication is key

Unlike traditional research, we don’t wait for publication before we communicate our findings. We regularly post research updates on our site and through email. Make sure you subscribe to our latest news.

Go ahead.

Imagine your life
when there is a cure.

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

What are the advantages of giving from your Donor Advised Fund (DAF)?

  • Your gifts to your donor advised fund entitle you to an immediate income tax deduction at the time of contribution.
  • You avoid capital gains tax on appreciated assets you place in your donor advised fund.
  • Your fund’s investment gains accumulate tax free.
  • Funds are distributed to Open Medicine Foundation in your name and immediately put to use to support our worldwide research efforts.

How do I make a donation through my DAF?

Just click on the DAF widget below. It is simple and convenient to find your fund among the over 900 funds in our system.

Still can’t find your fund? 

  • Request a grant distribution through your Donor Advised Fund sponsor
  • Be sure to use OMF’s EIN #26-4712664
  • You can also designate OMF as a beneficiary for your Donor Advised Fund
  • Questions? Give us a call at 650-242-8669