Multi-Omic Approaches to Solve Post-Acute COVID-19 (MOSAIC)

Despite the myriad of symptoms that patients can have with “Long COVID”, it appears that there are common pathogenic mechanisms for those disparate symptoms. While ME/CFS researchers understand that viral insult combined with other factors likely contribute to the onset of ME/CFS and related conditions like FM, it is important to identify the molecular mechanisms leading to these conditions as well as how to discriminate ME/CFS from other types of long-term sequelae (e.g., neurological conditions, respiratory dysfunction) as early as possible among COVID-19 long-haulers. 

Such an approach can lead to the development of algorithms predicting their clinical trajectories. It also offers an opportunity to help COVID-19 long-haulers as well as ME/CFS patients to better understand the progression of the condition and provide insights to identify targeted treatment strategies through precision medicine. Finally, as ME/CFS has historically followed viral outbreaks, the study of COVID-19 long-haulers may shed light on post-infectious fatigue syndrome following infections other than COVID-19.