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Raman Spectrometry Based Biomarker Discovery
for Myalgic Encephalomyelitis (RASPBERRY-ME)

Principal Investigator
Alain Moreau, PhD

ME/CFS is a complex disease that affects multiple systems in the body. Traditionally, the medical field focuses on one system at a time, as in the way medical specialists are organized. Research studies are usually planned in similar ways, to look at just one aspect, such as immune, endocrine, gastrointestinal, etc. Although individual characteristics of ME/CFS have been identified through a wide range of research projects, we are still missing the bigger picture of how it all fits together.

The goal of this study is to identify ME/CFS’s biomolecular signature: a combination of unique biochemical characteristics that are present only in ME/CFS. It’s like painting a whole picture of the disease in biomolecular terms. The study will use Raman Spectroscopy (RS), a chemical analysis technique that can analyze a sample without destroying it. This can provide detailed information about the chemical characteristics of the structure of a sample, like blood, or even what’s inside a single cell, including phospholipids, lipoproteins, DNA/RNA, and amino acids. The RS technique is fast, does not require costly chemicals, and won’t destroy the sample. It works by passing light through the sample and measuring vibrations.

This research team has used RS technology previously to study a variety of diseases, including the SARS-CoV-2 virus (COVID) in saliva and plasma.

This new study will test blood and other samples from ME/CFS patients, both at rest and after an exercise challenge, to fully characterize the baseline and changes seen after exertion. These will be compared to samples from healthy controls. It is anticipated that these full pictures of the biochemistry of ME/CFS will help researchers to differentiate between severely ill patients and those who are more mildly affected.

Results from this study will be combined with other research to better understand how ME/CFS affects the body at a biochemical level. This will create a more complete picture of the disease as a whole. It is hoped that these results can be used to develop diagnostic tests for ME/CFS, help doctors choose treatments, and determine whether the treatments are effective.

Learn more at


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Thanks to you, we’ve made incredible strides in collaborative research. Studies like this, have laid the foundation for OMF to move forward with small clinical trials!*

Successful small clinical treatment trials will lead to larger clinical trials using existing and new drugs. Small clinical trials, if found to be effective, are the best way to fast-track treatment. Accelerating research is our top priority at OMF. Let’s make this year better than ever by restoring hope and health together.

* Please note, we are still in the planning and development phase of treatment trials. We are not actively recruiting patients for small treatment trials at this time.


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 2022 OMF
Supported Research Activities

So far this year, we have already funded over $5.5 million in research activities. We are excited to
share the following list of projects that we have funded in 2022.


Throughout #TripleGivingTuesday, we will be featuring overviews of select projects. Stay tuned for more information!


Learn More

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

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